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BIOE 800 Bioengineering Colloquium

All seminars take place from 4:00 p.m. - 5:00 p.m. in 3150 Learned Hall, unless otherwise specified.

 

FALL 2014

 

September 5

Stevin Gehrke, Ph.D.

New Fall 2014 students ONLY.  This is a colloquium review session. 

 

September 12

Mehmet Sarikaya, Ph.D.

Professor of Materials Science and Engineering, The University of Washington

 

Molecular Biomimetics: Genetically Engineered Peptide-Enabled Materials & Systems for Technology & Medicine

Genetically Engineered Peptides for Inorganic solids (GEPI) are of a broad interest due to their capability for the functionalization of solids and their use as molecular linkers, erector sets and assemblers as well as tiny enzymes to synthesize nanosolids in molecular-technology and molecular-medicine. Further refining combinatorial mutagenesis approaches, e.g., cell surface and phage display libraries, that we have originally adapted from the principles of drug design, our laboratory has been experimentally selecting 1000s of solid-binding peptides for a variety of metals (Au, Pt, Au, Ti), oxides (ZnO, Alumina, Zirconia), semiconductors (GaN, MoS2, WSe2), and minerals(HAp, Quartz, Calcite, diamond, sapphire, and graphite). To accelerate the directed evolution process, we have also established bioinformatics methods to de novo design multifunctional peptides in chimeric constructs. Despite their short sequences (7-14 AA) and, hence, intrinsically disordered structures in water, the versatility of these peptides stem from their predictable folding conformations that is specific to a given solid surface with known physico-chemical characteristics. More recently, we have developed rational approaches to address, exclusively, the peptide-solid and peptide-peptide molecular interactions (while bound to a surface) of a given GEPI via point and domain mutations. Based on the understanding of the fundamental surface phenomena, e.g., diffusion, self-assembly, and surface organization, the novel approach allows us to construct peptide-enabled hybrid nanostructures with addressable chemical or physical functions. We will discuss latest developments in designing solid-binding peptides with specific surface recognition and assembly characteristics augmented by computational modeling (MD, MM, QM, kMC, etc.) and, finally, present examples in nanotechnology and nanomedicine implementations, e.g., in quantum dot assembly on LED displays, graphene FET cancer biosensors, biofunctionalization of implants (biocompatibility), and cell-free tissue reconstruction (dental repair).
 

Biosketch

 

October 3        3:30-4:30

Tim Topoleski, Ph.D.

Professor of Mechanical Engineering; University of Maryland, Baltimore County

 

Biomaterials: Soul & Machine
The most recent exhibit at the American Visionary Art Museum in Baltimore was called "Human, Soul & Machine: The Coming Singularity!"  In the biomaterials field, we are at the front of the envelop enhancing the quality of life for patients using implants, materials, and engineered tissue, and using approaches that have been  traditionally used in non-human, i.e., machine, applications.  In this presentation, I will talk about some of our past and recent work in biomaterials - in both implantable materials, and studying human tissue as a material. Perhaps this may lead us (speaker and audience) into a discussion of what is a machine, and how can we in the biomaterials field can continue to improve the quality of life for our friends, family, and colleagues using our engineering approaches.

 

October 17

Clay Quint, M.D., Ph.D.

The University of Kansas Medical Center

Tissue Engineering Vascular Grafts

Clay Quint is a Vascular Surgeon-Scientist who is using tissue engineering approaches for surgical applications in vascular disease.

 

October 31

Sabeth Verpoorte, Ph.D.

Chair of Analytical Chemistry and Pharmaceutical Analysis

Groningen Research Institute of Pharmacy

University of Groningen, The Netherlands

 

Leveraging Microfluidics for the Life Sciences

Sabeth Verpoorte is Chair of Analytical Chemistry and Pharmaceutical Analysis at the University of Groningen in The Netherlands. Her present research has a strong cell biological / pharmacological focus, and includes innovative joint projects with colleagues in pharmacokinetics and medical biology. Efforts have also concentrated on continuous-flow particle separation strategies, as well as miniaturized analytical instrumentation (paper spray ionization, multidimensional chromatography). This presentation will include examples from our research program.

 

November 14

HACKATHON --- ALL students must be present on the Lawrence campus for this session

Stephen Waller, M.D. - Associate Professor of Internal Medicine: Infectious Disease

Richard Gilroy, M.D. - Associate Professor and Medical Director of Liver Transplantation

The University of Kansas Medical Center

Gregory Thomas

Director, Center for Design Research; The University of Kansas

 

Synopsis coming soon 

 

December 5

Speaker TBD

 

 

SPRING 2015

 

January 23

Stevin Gehrke, Ph.D.

New Spring 2015 students ONLY.  This is a colloquium review session. 

 

February 6

Suzanne Shontz, Ph.D.

Professor of Electrical Engineering and Computer Science, The University of Kansas

 

Synopsis coming soon

 

February 20

Speaker TBD

 

March 27

Speaker TBD

 

April 10

Speaker TBD

 

April 24

Speaker TBD

 

May 7

Speaker TBD

 

 

 


 


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