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BIOE 800 Bioengineering Colloquium

All seminars take place from 4:00 p.m. - 5:00 p.m. in 3150 Learned Hall, unless otherwise specified.

 

FALL 2014

 

September 5

Stevin Gehrke, Ph.D.

New Fall 2014 students ONLY.  This is a colloquium review session. 

 

September 12

Mehmet Sarikaya, Ph.D.

Professor of Materials Science and Engineering, The University of Washington

 

Molecular Biomimetics: Genetically Engineered Peptide-Enabled Materials & Systems for Technology & Medicine

Genetically Engineered Peptides for Inorganic solids (GEPI) are of a broad interest due to their capability for the functionalization of solids and their use as molecular linkers, erector sets and assemblers as well as tiny enzymes to synthesize nanosolids in molecular-technology and molecular-medicine. Further refining combinatorial mutagenesis approaches, e.g., cell surface and phage display libraries, that we have originally adapted from the principles of drug design, our laboratory has been experimentally selecting 1000s of solid-binding peptides for a variety of metals (Au, Pt, Au, Ti), oxides (ZnO, Alumina, Zirconia), semiconductors (GaN, MoS2, WSe2), and minerals(HAp, Quartz, Calcite, diamond, sapphire, and graphite). To accelerate the directed evolution process, we have also established bioinformatics methods to de novo design multifunctional peptides in chimeric constructs. Despite their short sequences (7-14 AA) and, hence, intrinsically disordered structures in water, the versatility of these peptides stem from their predictable folding conformations that is specific to a given solid surface with known physico-chemical characteristics. More recently, we have developed rational approaches to address, exclusively, the peptide-solid and peptide-peptide molecular interactions (while bound to a surface) of a given GEPI via point and domain mutations. Based on the understanding of the fundamental surface phenomena, e.g., diffusion, self-assembly, and surface organization, the novel approach allows us to construct peptide-enabled hybrid nanostructures with addressable chemical or physical functions. We will discuss latest developments in designing solid-binding peptides with specific surface recognition and assembly characteristics augmented by computational modeling (MD, MM, QM, kMC, etc.) and, finally, present examples in nanotechnology and nanomedicine implementations, e.g., in quantum dot assembly on LED displays, graphene FET cancer biosensors, biofunctionalization of implants (biocompatibility), and cell-free tissue reconstruction (dental repair).
 

Biosketch

 

October 3        3:30-4:30

Tim Topoleski, Ph.D.

Professor of Mechanical Engineering; University of Maryland, Baltimore County

 

Biomaterials: Soul & Machine
The most recent exhibit at the American Visionary Art Museum in Baltimore was called "Human, Soul & Machine: The Coming Singularity!"  In the biomaterials field, we are at the front of the envelop enhancing the quality of life for patients using implants, materials, and engineered tissue, and using approaches that have been  traditionally used in non-human, i.e., machine, applications.  In this presentation, I will talk about some of our past and recent work in biomaterials - in both implantable materials, and studying human tissue as a material. Perhaps this may lead us (speaker and audience) into a discussion of what is a machine, and how can we in the biomaterials field can continue to improve the quality of life for our friends, family, and colleagues using our engineering approaches.

 

October 17

Clay Quint, M.D., Ph.D.

The University of Kansas Medical Center

Tissue Engineering Vascular Grafts

Clay Quint is a Vascular Surgeon-Scientist who is using tissue engineering approaches for surgical applications in vascular disease.

 

October 31

Sabeth Verpoorte, Ph.D.

Chair of Analytical Chemistry and Pharmaceutical Analysis

Groningen Research Institute of Pharmacy

University of Groningen, The Netherlands

 

Leveraging Microfluidics for the Life Sciences

Sabeth Verpoorte is Chair of Analytical Chemistry and Pharmaceutical Analysis at the University of Groningen in The Netherlands. Her present research has a strong cell biological / pharmacological focus, and includes innovative joint projects with colleagues in pharmacokinetics and medical biology. Efforts have also concentrated on continuous-flow particle separation strategies, as well as miniaturized analytical instrumentation (paper spray ionization, multidimensional chromatography). This presentation will include examples from our research program.

 

November 14

HACKATHON --- ALL students must be present on the Lawrence campus for this session

Stephen Waller, M.D. - Associate Professor of Internal Medicine: Infectious Disease

Richard Gilroy, M.D. - Associate Professor and Medical Director of Liver Transplantation

The University of Kansas Medical Center

Gregory Thomas

Director, Center for Design Research; The University of Kansas

 

Fundamental Changes in Hospital Room Design
 
This colloquium will be an interactive event where participants can put on their thinking caps and consider the issue of the hospital room.  The Affordable Care Act has put the burden on hospitals to reduce hospital based infections and accidents (such as falls).  The hospital room remains a source for these issues with equipment, tubing, power cords, tray tables and personal belongings all fighting for limited floor space and blocking easy movement of patients, staff and guests.  In this colloquium we will examine these issues and brainstorm solutions. 

 

 

December 5

Rodrigo Perea, Ph.D. Candidate

The University of Kansas Bioengineering Graduate Program

 

The Effects of  Exercise on Brain's Structural Connectivity in the Alzheimer's Disease

Alzheimer's disease is a neurodegenerative disease that affects cognition in the elderly, decreases quality of life and at the late stages leads to death.  It affects one in nine people over the age of 65 and one in three over the age of 85. The cause of the disease is unknown and to date there is no cure. At early stages, pharmacological treatments improve clinical symptoms but do not slow down brain deterioration. Thus, emerging research focuses on aerobic exercise as a potential treatment. In animal models, evidence showed that aerobic exercise increases neurogenesis and improves cognition. In early AD humans studies, in-vivo structural resonance imaging have also shown positive associations between exercise and increased brain volumes. Yet there is no little evidence on how exercise affects the structural connectivity of the brain. Thus, my research explore further the effects of exercise on brain's white matter structural connectivity using diffusion tensor imaging (DTI). DTI is a magnetic resonance imaging technique that measures random displacements of water molecules by applying magnetic gradient pulses.

 

SPRING 2015

 

January 23

Stevin Gehrke, Ph.D.

New Spring 2015 students ONLY.  This is a colloquium review session. 

 

February 6

Suzanne Shontz, Ph.D.

Professor of Electrical Engineering and Computer Science, The University of Kansas

 

Synopsis coming soon

 

February 20

Dan A. Dixon, Ph.D.

Co-Leader, Cancer Prevention Program, University of Kansas Cancer Center

 

Synopsis coming soon

 

March 27

Speaker TBD

 

April 10

Speaker TBD

 

April 24

Speaker TBD

 

May 7

Speaker TBD

 

 

 


 


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