Fall 2018

All seminars take place on Mondays from 4:00 pm - 5:00 pm in LEEP2 2420, unless otherwise specified.


August 20th: 

4:00pm in LEEP2 2420

Speaker:  Denise Bridwell

New Fall 2018 students only

Colloquium review

 

August 27thThe application of antivascular photo-mediated ultrasound therapy in removing microvessels

Speaker:  Xinmai Yang, Ph.D.

Director: Bioimaging, Associate Professor: Mechanical Engineering

Abstract: Antivascular therapy represents a proven strategy to improve the prognosis of a variety of pathological conditions, including cancer and many eye diseases.  By synergistically applying laser pulses and ultrasound bursts, we developed a novel photo-mediated ultrasound therapy (PUT) technique as a localized antivascular method.  PUT takes advantages of the high native optical contrast between biological tissues, and has the unique capability to self-target microvessels without causing unwanted damages to the surrounding tissue.  Through in vitro experiments and theoretical simulations, we demonstrate that cavitation might have played a key role in PUT.  In animal experiments, we demonstrate that PUT can treat microvessels in target tissue via different mechanisms, which include blocking microvessels by inducing blood clots and disrupting microvessels by causing local hemorrhage.  Moreover, PUT working at different optical wavelengths can selectively treat veins or arteries by utilizing the contrast in the optical spectra between deoxy- and oxy-hemoglobin.  Specifically, PUT can be applied to precisely remove choroidal blood vessels in the eye, and result in significantly reduced blood perfusion in the choroidal layer which persisted to four weeks without causing collateral tissue damage, demonstrating that PUT is capable of removing choroidal microvasculature safely and effectively. With its unique advantages, PUT holds great potential for the clinical management of eye diseases associated with microvessels and neovascularization. 

September 17th: 

Speaker:  Jim West, Ph.D.

 

October 1stTwo objectives, one goal: advance understanding of gap junctions’ role in coupled microcircuits

Speaker:  Eduardo Rosa-Molinar, Ph.D.

Director of Microscopy and Analytical Imaging Research Resource Core Laboratory, Professor of Pharmacology and Toxicology and Neuroscience Graduate Program, University of Kansas

AbstractMy presentation will highlight two decades of simultaneously working to: 1) build a gap junction synaptome and 2) develop labels and new tissue preparation reagents and workflows to permit imaging the three-dimensional (3-D) nanoscale geometry and metal ions associated with GJs-coupled microcircuits. Achieving both objectives is required to elucidate gap junctions’ (GJs) role in regulating fast GJ-coupled microcircuits.  Research supported by GM-115042, MH-106245, and HRD-1736019.

October 22nd:   

Speaker:  John Peter Ralston, Ph.D.

 

November 5th:         

Speaker:  Rachel Chevalier, M.D.

Volunteer Assistant Professor of Pediatrics

 

November 12th

Speaker:  Neil Segal, M.D.,M.S.

 

November 26th

Speaker:  Richard Barohn, M.D.

Director of Frontiers: The Hearthland Institute for Clinical and Translational Research, Principle investigator on the National Institutes of Health Clinical and Translational Science Award