BIOE 800 Bioengineering Colloquium
All seminars take place from 4:00 p.m. - 5:00 p.m. in 3150 Learned Hall, unless otherwise specified.
You’re welcome to join us online through the following link: http://desktopconnect.ku.edu/bioecoll and be sure to log in as a guest.
Stevin Gehrke, Ph.D.
New Spring 2015 students ONLY. This is a colloquium review session.
Suzanne Shontz, Ph.D.
Professor of Electrical Engineering and Computer Science, The University of Kansas
A Computational Framework for Predicting Inferior Vena Cava Filter Performance on a Patient-Specific Basis
Pulmonary embolism (PE) is a potentially-fatal disease in which blood clots (i.e., emboli) break free from the deep veins in the body and migrate to the lungs. In order to prevent PE, anticoagulants are often prescribed; however, for some patients, anticoagulants cannot be used. For such patients, a mechanical filter, namely an inferior vena cava (IVC) filter, is inserted into the IVC to trap the blood clots and prevent them from reaching the lungs. There are numerous IVC filter designs, and it is not well understood which particular IVC filter geometry will result in the best treatment for a given patient. Patient-specific computational fluid dynamic (CFD) simulations may be used to predict the performance of IVC filters and hence can aid physicians in IVC filter selection and placement.
In this talk, I will first describe our computational pipeline for prediction of IVC filter performance. Our pipeline involves several steps including image processing, geometric model construction, in vivo stress state estimation, surface and volume mesh generation based on virtual IVC filter placement, and CFD simulation of IVC hemodynamics. I will then present the results of our IVC hemodynamics simulations obtained for two patient IVCs.
This talk represents joint work with several researchers at The Pennsylvania State University, Penn State Hershey Medical Center, the Penn State Applied Research Lab, and the University of Utah.
Program Assistant, KU Bioengineering Graduate Program
Equipped to Succeed: How Sales Skills Help You Achieve Your Goals
In a world where we are all vying for something, what is going to set you apart from everyone else?
Personally and professionally, we find ourselves in sales situations every day. In this session we will examine the basic principles of selling and apply them to our everyday lives. After all…you may have the greatest scientific breakthrough of the century but if you can’t get your message across or get anyone to buy in, it will not reach its full potential.
This will be an interactive session so in person attendance is advantageous.
Dan A. Dixon, Ph.D.
Co-Leader, Cancer Prevention Program, University of Kansas Cancer Center
The Impact of Altered mRNA Decay in Colorectal Cancer
Colorectal cancer (CRC) is a devastating disease that will affect 1 in 20 people in the US. While deaths from CRC has improved over the past decade due to increased emphasis on preventive screening, this widespread disease continues to rank as one of the top cancers in incidence and mortality. CRC tumors arise from mutations that activate oncogenes and cause loss of tumor suppressors. As a consequence of these defects, signaling pathways become activated, leading to enhanced expression of growth factors and inflammatory mediators that fuel tumor growth. In normal intestinal epithelium, these genes serve to maintain intestinal homeostasis. However, critical mechanisms controlling gene expression on the post-transcriptional level are lost during tumor development. Our work focuses on these mechanisms involving RNA-binding proteins and microRNAs that "seek-and-destroy" these oncogenic mRNAs through rapid degradation. Using molecular, cellular, and in vivo approaches, we are examining the functional significance post-transcriptional regulation plays in controlling CRC tumor progression, along with testing novel therapeutic approaches targeting mRNA stabilization in tumor cells and identifying new CRC biomarkers for prevention.