BIOE 800 Bioengineering Colloquium
All seminars take place from 4:00 p.m. - 5:00 p.m. in 3150 Learned Hall, unless otherwise specified.
Stevin Gehrke, Ph.D.
New SPRING 2014 students ONLY. This is a colloquium review session.
Anil Misra, Ph.D.
Professor; Civil, Environmental and Architectural Engineering; University of Kansas
Kenneth R. Diller, Sc.D., P.E.
Biomedical Engineering, The University of Texas
“Novel Temperature Based Devices for New Therapeutic Procedures”
Controlled surface cooling and heating of the skin can be a powerful means for treating a wide range of therapeutic needs. These include such diverse medical conditions as stroke, traumatic brain injury, orthopedic surgery trauma, and sleep disorders. Nearly all of these thermally based methods make use of the ability to control blood flow via an applied stimulation temperature. Devices must provide both therapeutic efficacy and safety. Many devices may be designed to combine functional simplicity with physiological sophistication. Engineering challenges embodied in inventing and developing such devices will be illustrated and discussed.
March 7 12:00-1:00pm
Brendan Harley, Sc.D.
Assistant Professor; Chemical and Biomolecular Engineering, Institute for Genomic Biology
University of Illinois at Urbana-Champaign
The extracellular matrix (ECM) is a complex organization of structural proteins such as collagens and proteoglycans. Understanding that the ECM is dynamic and often spatially patterned or heterogeneous over the length-scale of traditional biomaterials, we are developing instructive biomaterials that present microenvironmental cues in spatially and temporally defined manners. I will describe development of a collagen biomaterial to address critical barriers preventing regeneration of orthopedic insertions such as the osteotendinous (tendon-bone) junction. Here, replicating spatial gradients in mineral content and matrix anisotropy across a single biomaterial construct enables us to drive mesenchymal stem cell (MSC) differentiation down osteotendinous lineages in a spatially-selective manner. Further, we have created bioinspired core-shell structures (e.g., porcupine quills) in order to balance bioactivity and mechanical competence concerns. I will subsequently describe a microfluidic forming technique to create libraries of optically-translucent hydrogels containing overlapping patterns of cell, matrix, and biomolecule cues. We are using this ‘tissue biochip’ platform to dissect the coordinated impact of spatially-organized cell and matrix signals on(1) niche-mediated regulation of hematopoietic stem cell fate; and (2) the malignancy and therapeutic response of human glioblastoma multiforme cells. I will show how these biomaterial platforms can be used as rheostats to regulate critical cellular processes such as stem cell self-renewal vs. differentiation; tissue regeneration and vascularization; and the etiology and malignancy of cancer.
Wayne Carter, DVM, PhD, DACVIM
Kansas City Area LIfe Sciences Institute, President and CEO
“Technology Development for Translational Medicine”
Translational medicine is often described as accelerating the time from bench science to clinical application. Dr. Wayne Carter led Translational Medicine and Clinical Technology Development for Pfizer for 11 years and will review some of the technologies developed to accelerate drug development decisions and the need for bioengineering, mathematical modeling and the value of a diverse team approach.
KUMC students should plan to be on the Lawrence campus for this session.
Sara Myers, Ph.D.
Assistant Professor, School of Health, Physical Education and Recreation, University of Nebraska at Omaha
Synopsis coming soon.
Director; Environment, Health and Safety; University of Kansas
Synopsis coming soon