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BIOE 800 Bioengineering Colloquium

All seminars take place from 4:00 p.m. - 5:00 p.m. in 3150 Learned Hall, unless otherwise specified.

 

SPRING 2014

 

January 24

Stevin Gehrke, Ph.D.

New SPRING 2014 students ONLY.  This is a colloquium review session. 

 

February 7

Anil Misra, Ph.D.

Professor; Civil, Environmental and Architectural Engineering; University of Kansas

"Hard and Soft Micromechanics of Biomaterials"
 
Biomaterials are characterized by scale-dependent composition and microstructures.  When describing mechanical properties of these materials it is desirable to apply appropriate micromechanical models that to some extent incorporate the microstructural/compositional information to enable the understanding of the scale-dependency.  Micromechanical models also become necessary when we seek to interpret material properties from laboratory measurements, especially those using high resolution techniques which seldom measure the properties directly.  Two examples of micromechanical models one applicable hard mineralized material (dentin) and the other to soft chemically active fibrous materials will be presented.  It will be shown that these models enable us to describe the material properties in terms of microstructure and composition, and provide insights that are unavailable from measurements alone.

 

February 28

Kenneth R. Diller, Sc.D., P.E.

Biomedical Engineering, The University of Texas

“Novel Temperature Based Devices for New Therapeutic Procedures”

Controlled surface cooling and heating of the skin can be a powerful means for treating a wide range of therapeutic needs. These include such diverse medical conditions as stroke, traumatic brain injury, orthopedic surgery trauma, and sleep disorders. Nearly all of these thermally based methods make use of the ability to control blood flow via an applied stimulation temperature. Devices must provide both therapeutic efficacy and safety. Many devices may be designed to combine functional simplicity with physiological sophistication. Engineering challenges embodied in inventing and developing such devices will be illustrated and discussed.

 

March 7  12:00-1:00pm

Brendan Harley, Sc.D.

Assistant Professor; Chemical and Biomolecular Engineering, Institute for Genomic Biology

University of Illinois at Urbana-Champaign

The extracellular matrix (ECM) is a complex organization of structural proteins such as collagens and proteoglycans. Understanding that the ECM is dynamic and often spatially patterned or heterogeneous over the length-scale of traditional biomaterials, we are developing instructive biomaterials that present microenvironmental cues in spatially and temporally defined manners. I will describe development of a collagen biomaterial to address critical barriers preventing regeneration of orthopedic insertions such as the osteotendinous (tendon-bone) junction. Here, replicating spatial gradients in mineral content and matrix anisotropy across a single biomaterial construct enables us to drive mesenchymal stem cell (MSC) differentiation down osteotendinous lineages in a spatially-selective manner. Further, we have created bioinspired core-shell structures (e.g., porcupine quills) in order to balance bioactivity and mechanical competence concerns. I will subsequently describe a microfluidic forming technique to create libraries of optically-translucent hydrogels containing overlapping patterns of cell, matrix, and biomolecule cues. We are using this ‘tissue biochip’ platform to dissect the coordinated impact of spatially-organized cell and matrix signals on(1) niche-mediated regulation of hematopoietic stem cell fate; and (2) the malignancy and therapeutic response of human glioblastoma multiforme cells. I will show how these biomaterial platforms can be used as rheostats to regulate critical cellular processes such as stem cell self-renewal vs. differentiation; tissue regeneration and vascularization; and the etiology and malignancy of cancer.

Brendan A. Harley, Sc.D. Flyer

 

March 28

Wayne Carter, DVM, PhD, DACVIM

Kansas City Area LIfe Sciences Institute, President and CEO

“Technology Development for Translational Medicine”

Translational medicine is often described as accelerating the time from bench science to clinical application.  Dr. Wayne Carter led Translational Medicine and Clinical Technology Development for Pfizer for 11 years and will review some of the technologies developed to accelerate drug development decisions and the need for bioengineering, mathematical modeling and the value of a diverse team approach.

KUMC students should plan to be on the Lawrence campus for this session. 

 

April 11

Sara Myers, Ph.D.

Assistant Professor, School of Health, Physical Education and Recreation, University of Nebraska at Omaha

"Gait biomechanics and variability in peripheral arterial disease"

Sara Myers is an Assistant Professor in the School of HPER and Assistant Director of the Biomechanics Research Building at the University of Nebraska Omaha. The Biomechanics Research Building utilizes the study of human movement variability to gain clinical insights and improve rehabilitation in various clinical populations. Dr. Myers' work with patients with peripheral arterial disease is currently funded by the VA Rehabilitation Research & Development program and the NIH to assess functional improvements before and after exercise and surgical treatments.


 

April 25

Mike Russell

Director; Environment, Health and Safety; University of Kansas

Synopsis coming soon

 

 

May 2

Stevin Gehrke, Ph.D.

This is a Qualifying Exam review session.  ONLY those students taking the Qualifying Exam this year are required to attend this session. 

 

 


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