All seminars take place on Mondays from 4:00 pm - 5:00 pm in LEEP2 2420, unless otherwise specified.
4:00pm in LEEP2 2420
February 12th: KU Environment, Health & Safety
Speaker: Mike Russell
What you need to know about Environment, Health, & Safety at KU
March 5th: Polymeric Micelles for Delivery of Gaseous Signal-Transmitter Molecules
Assistant Professor // Department of Chemical Engineering, Kansas State University // firstname.lastname@example.org
Gaseous signal-transmitter molecules such as nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H2S) have recently emerged as therapeutic gases with potential applications in treatment of various pathological conditions like cancer and cardiovascular diseases. Despite their interesting biological functions, the therapeutic potential of these gases has not been well explored due to the difficulty in handling of these gases. One common approach is to use small compounds (gas donors) that release gases under physiologically relevant conditions. However, most of gas donors reported so far show relatively fast gas release, which is not desirable for therapeutic applications that require sustained gas release. Another drawback is that small gas donors and/or their decomposition byproducts often show side effects, which blur the real biological activities of therapeutic gases.
To address the issues associated with the small gas donors, we have developed polymeric micelle-based gas donors. These gas donor micelles enable controlled release of gases within cells, inhibit toxic side effects and exhibit much higher biological activities in different cells compared to the corresponding small gas donors. In this talk, the design, synthesis and characterization of the block copolymer micelles as well as their biological evaluation in cell culture and the chick chorioallantoic membrane (CAM) assay will be presented to highlight the potential applications of the gas donor micelles in wound healing and cancer therapy.